TRH or thyrotropin releasing hormone is not a hormone at all but is in fact a tropic tripeptide made from three amino acids that occur naturally in the body. Thyroid releasing hormone is primarily produced in the hypothalamus in the brain. Its production is so important, not just in itself but to a whole chain of necessary hormonal processes including the metabolism and immune system.
Thyrotropin releasing hormone is ubiquitous in nature – from plants to animals, to humans we all need TRH for life to function.
Having a number of positive and far-reaching effects which are just coming to the fore, historically TRH has been used to treat Thyroid problems because it increases thyroid function and subsequently Thyrotropin levels. These, like many immunological and metabolic functions, are known to decrease as we age.
But in Dr Pierpaoli’s animal experiments TRH supplements have encouraged old animals to:
Essentially TRH’s job is to help the thyroid gland produce thyrotropin, which is vital to synthesise and use hormones effectively. TRH affects nearly every bodily function including the heart rate, metabolism, body temperature and growth.
This TRH supplement raises the efficiency in how our bodies process glucose (a function which naturally deteriorates with age) and by doing so, we can increase metabolism speed by increasing our metabolism - the Thyroid Releasing hormone becomes an effective weight loss treatment. Dr Pierpaoli has also documented that TRH hormones introduced into our bodies decrease leptin – which effectively regulates body weight and fat stores.
Recently he’s also documented the other remarkable roles it plays too, like improved kidney function.
Dr Pierpaoli advocates 5mg or 10mg of TRH taken sublingually first thing in the morning, ideally before rising from bed. Obviously the dose and the frequency depends on the need, but Dr Pierpaoli now believes that TRH need only be taken as a cycle of 20-days on and 20-days off. As a maximum taken for 20-days in a calendar month and the remainder of the month without. Therefore it is not necessary to take TRH every day.
Backed by one of the most famous physicians and researchers in Anti-aging medicine, the New York Times Bestselling author and world Melatonin expert Dr Walter Pierpaoli, who suggests that TRH is a ‘master’ hormone not just responsible for helping to adjust thyroid hormones, but in helping to correct many imbalances throughout the body.
Antiaging Systems is proud to be one of the first organizations in the world to offer Dr Pierpaoli’s own formula sublingual TRH.
Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical / published results.
How to use TRH in a euthyroid, healthy person? Does the TRH stimulate the release of thyroid hormones, are there increases in blood levels, are there any potential problems with hyperthyroid symptoms such as tachycardia, jitters etc.?
TRH has a misleading name, it is similar to prolactin for milk secretion. TRH has hardly anything to do with thyroid, as Dr. Pierpaoli has shown in his TRH experiments. TRH does not stimulate synthesis or secretion of thyroid hormones such as T3 and T4, but simply MAY reveal a deficiency of TSH in the pituitary gland. It does not produce any symptom of hyperthyroidism in euthyroid persons even at a very high dosage if given intravenously.
Should TRH be used if a person has thyroid problems? If so, does that apply for hypothyroidism, autoimmune (Hashimoto’s thyroiditis) or only perhaps to thyroid cancer, nodules and hyperthyroidism?
TRH is an ubiquitous molecule which has anticipated in evolution the physiology of our body. Strangely it is ignored that TRH is fundamental for oxidative phosphorylation and glucose consumption, for a real energy production and supply of oxygen to cells. Witout TRH in the beta cells of the pancres, we would be dead with hyperglycemic coma owing to blockade of insulin synthesis and production. Farnetications on genetics and molecular biology continues while the most elementary physiology is ignored! TRH can be used in all pathologies because its role is fundamental for e.g. enhancing immunity and defending the body from all hormonal and metabolic derangements. The ancestral role of TRH makes of TRH the most fundamental molecule ever seen for treatment of diseases.
I am considering purchasing TRH but would like a little more info. I am hypothyroid and have been for 30 years. I take Armour thyroid 2 1/2 grains. I have in the past gone hyperthyroid from taking too much thyroid. Will Abaris decrease my TSH or can I take it with my current dose of Armour? I would like to lose about 10lbs that are stubborn but don't want to go hyperthyroid.
Dr. Walter Pierpaoli replies; " TRH may increase TSH levels but only in patients with low TSH pituitary function. However the activity of TRH is negligible and misleading because TRH does not interfere at all with thyroid function! TRH is an independent basic entity which helps to correct the whole deranged neuroendocrine-immune system in aging persons.
Our pharmacist adds; "obviously you should continue to monitor your thyroid dose. The simplest way to do this is to record your morning- rising from bed- body temperature. Keep a thermometer and a notepad and pen by your bed. If over the course of approximately 2 weeks your temperature is often above normal body temperature of 97.8 to 98.2 degrees Fahrenheit then you may need to adjust your thyroid dose downward. Of course, if it is often less than 97.8 degrees F, then the thyroid dose may need to be adjusted upward."
I am interested in TRH but want to check two things before I purchase, firstly is it Ok for people with Hypertension to take? And secondly is there an age limit for taking TRH?
There are no known contraindications between TRH and hypertension in normal dosing. There is also no known upper age limit with TRH, although the usual conditions of gradual dosing with older individuals, as per all drugs, are advisable. Of course if the patients are consuming other medications, changes may need to be made to their program. Naturally all of this is conditional on the advice of your own personal physician. We hope this helps.
I would like to know if TRH effects Prolactin levels?
Dr. Walter Pierpaoli has advised us that in the 23 years he has been researching and using TRH, that he has not seen any significant increases in prolactin levels in TRH patients. He goes on to say that there are published papers out there that may suggest that TRH may have some influence on prolactin, but that these are at very high dosage and when it is administered intravenously. Therefore, there is very little chance of such effects when used at 5 to 10mg daily sublingually.
I have been taking 150mcg of Syntheroid for 8 yrs . May I discontinue the Syntheroid when I receive my TRH shipment. I do not wish to feel hyper. I am 78 yrs. old and bicycle 3 miles every day. I am 6'2" weigh 200 lbs. and am on Benecar 20 mg per day blood pressure medication and do not wish to get blood pressure spikes from the combo of TRH and Syntheroid.
The use of TRH, as Dr. Pierpaoli has pointed out in his published papers and also in our recent interview with him - does not affect the thyroid gland as much as its name and reputation suggests. But none-the-less there can be improvements to the release of various thymus hormones with its use; unfortunately it is difficult to be precise and suggest to you that you will be able to discontinue Synthroid completely- there is a better chance that you will be able to reduce its dose however.
By the way, we have many supporting articles on our website about the use of natural thyroids vs. Synthroid® (T4) and you may want to look into these. In the vast majority of cases patients perform better on a natural thyroid like Armour® than on one of the synthetics- as you are taking. There are a number of reasons for this, not least of all that the natural thyroids contain all four thymus hormones including T3 and T4, including the ‘forgotten’ T1 and T2.
Obviously it will be in your interest to measure your heart rate and blood pressure, but the classic way to ensure that your thyroid is not overactive (or for that matter underactive) is to measure your rising from bed body temperature. Those details are contained within Dr. Ward Dean’s article here.
TRH (thyrotropin releasing hormone) is a natural hormone for growth which can be used to increase metabolism and promote weight loss.
TRH (thyrotropin releasing hormone) or Thyroid stimulating hormone (TSH) is a hormone supplement which increases thyroid function and helps you stay healthy.
TRH (thyrotropin releasing hormone) or Thyroid stimulating hormone (TSH) is produced naturally from the thyroid gland, and has far reaching health benefits, such as strengthening our immune systems. Like many metabolic functions, TRH (thyrotropin releasing hormone) decreases as we age, which is why TRH supplement is so beneficial.
Thyrotropin levels in the body can be ascertained through a simple thyrotropin test. If this thyrotropin test reveals low Thyrotropin levels a daily TRH supplement will soon have you feeling fit and healthy again.
TRH (thyrotropin releasing hormone) increases thyroid function, which in turn increases metabolism speed, which effectively regulates our body weight and how quickly our body uses energy. The effects of TRH Abaris tablet are almost immediate, restoring youthful energy levels once more.
What is Abaris™?
Each Abaris™ tablet contains 5 mg Protirelin (thyrotropin-releasing hormone) and the excipients; sorbitol, sucrose, microcrystalline cellulose, talc, colloidal silica and dehydrogenated castor oil.
What is Abaris™ used for?
This medicine has been prescribed for you by your doctor to treat and adjust your metabolic disorders resulting into clear (or initial) hyperglycemia (high sugar levels), high blood pressure, high lipid levels and water retention, all consequent to overt or insidious hypothyroidism.
How does Abaris™ work?
Abaris™ works by accelerating the digestion of carbohydrates (complex sugars) from your diet, and reducing abnormally high blood sugar levels that occur after each meal. This is achieved by a combined activation of both insulin secretion in the beta cells of the pancreas and also by promotion of thyroid function by physiological cooperation.
It must be noticed that Abaris™ is a molecule produced by our body in order to regulate insulin secretion and sugar levels. However it also acts by regulating thyroid function; in case it is low, as is often the case in most individuals after the age of 40-50. In fact, its original name of thyrotropin-releasing hormone corresponds to its effect on the stimulation of the pituitary hormone TSH.
Possible adverse effects
There are no known allergic reactions, but caution must be adopted in case you are allergic to its excipients. If you are unsure about this ask your doctor.
Although there is no evidence that Abaris™ would worsen the conditions mentioned below, you should not take Abaris™ if you have any of the following medical conditions:
If you are unsure whether you might have any of these conditions, please ask your doctor before taking Abaris™.
What precautions should I take?
If you are treating hyperglycemic episodes (hypos), then as a diabetic you may also be receiving other treatments for your diabetes. If you are taking insulin or sulphonylurea drugs to control your blood sugar, you will probably be used to avoiding hypoglycemic episodes by taking sugar when you feel that your blood sugar level is too low. Make sure you consult your doctor before using Abaris™ if this is the case.
If you are also taking thyroid medication, there is a need to monitor your thyroid levels closely, either via a blood test that your doctor will advise you on, or by monitoring your rising from bed body temperature strictly between 7 and 8 AM, to ensure it is between 36 and 36.4 degrees Celsius. If your temperature is constantly below 36°C you may need to increase your thyroid dose, more likely to occur when combined with TRH use. If your temperature rises above 36.4°C then you may need to slightly reduce your thyroid dosage. Your doctor will advise you on the precise course of action required.
When and how do I take Abaris™?
You should adhere to the program prescribed for you by your doctor. This will also help in reducing any side-effects that you may experience. Take the tablets as prescribed by your doctor. This will normally be one or two 5-mg tablets taken sublingually (under the tongue) in the early morning while you are still in bed.
The tablets must be dissolved entirely under the tongue and the saliva kept under your tongue in close contact with the superficial sublingual venous plexus for at least 10-minutes. This allows maximal adsorption into the blood stream.
For short term use, a cyclic program of 20-days and then a rest period of one month is adequate and then repeated. The treatment can be enhanced and potentiated in case of severe metabolic pathologies. For an evaluation of its effects, it is suggested to monitor blood sugar, lipids levels and blood pressure in the morning, before and after the 20-day treatment and make a comparison to the pre-treatment values.
What undesirable effects may I experience?
DO NOT EXCEED THE PRESCRIBED DOSE. Although to the best of our knowledge, Abaris™ produces no side-effects even if injected intravenously at a very high dosage. The molecule is immediately dissipated in the blood and has few side effects when taken by the oral route even at high dosages.
IF YOU EXPERIENCE ANY UNDESIRABLE EFFECTS, STOP USE AND TELL YOUR DOCTOR IMMEDIATELY. YOUR DOCTOR WILL GIVE YOU FURTHER ADVICE.
What should I do if I miss one or more doses?
There are no serious consequences other than reduction of minor therapeutic effects. Do not try to increase the dose at a later date; simply continue the program normally at your earliest opportunity.
How should I store my Abaris™ tablets?
It is best if you keep your tablets in the original carton supplied. The tablets should be kept in a dry place where the temperature is not likely to exceed 25°C. KEEP OUT OF THE REACH OF CHILDREN. Do not use tablets beyond the expiry date. If you find that you have tablets after their expiry date, return them to your local pharmacist who will dispose of them properly.
REMEMBER: THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. DO NOT GIVE IT TO ANYONE ELSE UNDER ANY CIRCUMSTANCES. IF YOU HAVE ANY DOUBTS ABOUT TAKING ABARIS™ CORRECTLY SEEK THE ADVICE OF YOUR DOCTOR
TRH Abaris 30 x 5 ml Sublingual Tablets
Contains Thyroliberin 5ml
Excipients: Missing table
Directions: Take one tablet under your tongue early in the morning before food. Do not chew. Please wait until all the tablet has dissolved under your tongue. Please note this may take up to 10 minutes.
For long term storage keep in refrigerator.
Always follow the advice of your physician.
Disclaimer: This product and its statements have not been evaluated by the FDA. This product is not intended to treat cure or prevent disease.
Distributed by Profound Products, PO Box 19, Sark, Great Britain