TRH or thyrotropin releasing hormone is not a hormone at all but is in fact a tropic tripeptide made from three amino acids that occur naturally in the body. Thyroid releasing hormone is primarily produced in the hypothalamus in the brain. Its production is so important, not just in itself but to a whole chain of necessary hormonal processes including the metabolism and immune system.
Thyrotropin releasing hormone is ubiquitous in nature – from plants to animals, to humans we all need TRH for life to function.
Having a number of positive and far-reaching effects which are just coming to the fore, historically TRH has been used to treat Thyroid problems because it increases thyroid function and subsequently Thyrotropin levels. These, like many immunological and metabolic functions, are known to decrease as we age.
But in Dr Pierpaoli’s animal experiments TRH supplements have encouraged old animals to:
Watch our interview with Dr Pierpoali about TRH below
Essentially TRH’s job is to help the thyroid gland produce thyrotropin, which is vital to synthesise and use hormones effectively. TRH affects nearly every bodily function including the heart rate, metabolism, body temperature and growth.
This TRH supplement raises the efficiency in how our bodies process glucose (a function which naturally deteriorates with age) and by doing so, we can increase metabolism speed by increasing our metabolism - the Thyroid Releasing hormone becomes an effective weight loss treatment. Dr Pierpaoli has also documented that TRH hormones introduced into our bodies decrease leptin – which effectively regulates body weight and fat stores.
Recently he’s also documented the other remarkable roles it plays too, like improved kidney function.
Dr Pierpaoli advocates 5mg or 10mg of TRH taken sublingually first thing in the morning, ideally before rising from bed. Obviously the dose and the frequency depends on the need, but Dr Pierpaoli now believes that TRH need only be taken as a cycle of 20-days on and 20-days off. As a maximum taken for 20-days in a calendar month and the remainder of the month without. Therefore it is not necessary to take TRH every day.
Backed by one of the most famous physicians and researchers in Anti-aging medicine, the New York Times Bestselling author and world Melatonin expert Dr Walter Pierpaoli, who suggests that TRH is a ‘master’ hormone not just responsible for helping to adjust thyroid hormones, but in helping to correct many imbalances throughout the body.
Antiaging Systems is proud to be one of the first organizations in the world to offer Dr Pierpaoli’s own formula sublingual TRH.
Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical / published results.
How to use TRH in a euthyroid, healthy person? Does the TRH stimulate the release of thyroid hormones, are there increases in blood levels, are there any potential problems with hyperthyroid symptoms such as tachycardia, jitters etc.?
TRH has a misleading name, it is similar to prolactin for milk secretion. TRH has hardly anything to do with thyroid, as Dr. Pierpaoli has shown in his TRH experiments. TRH does not stimulate synthesis or secretion of thyroid hormones such as T3 and T4, but simply MAY reveal a deficiency of TSH in the pituitary gland. It does not produce any symptom of hyperthyroidism in euthyroid persons even at a very high dosage if given intravenously.
Should TRH be used if a person has thyroid problems? If so, does that apply for hypothyroidism, autoimmune (Hashimoto’s thyroiditis) or only perhaps to thyroid cancer, nodules and hyperthyroidism?
TRH is an ubiquitous molecule which has anticipated in evolution the physiology of our body. Strangely it is ignored that TRH is fundamental for oxidative phosphorylation and glucose consumption, for a real energy production and supply of oxygen to cells. Witout TRH in the beta cells of the pancres, we would be dead with hyperglycemic coma owing to blockade of insulin synthesis and production. Farnetications on genetics and molecular biology continues while the most elementary physiology is ignored! TRH can be used in all pathologies because its role is fundamental for e.g. enhancing immunity and defending the body from all hormonal and metabolic derangements. The ancestral role of TRH makes of TRH the most fundamental molecule ever seen for treatment of diseases.
I am considering purchasing TRH but would like a little more info. I am hypothyroid and have been for 30 years. I take Armour thyroid 2 1/2 grains. I have in the past gone hyperthyroid from taking too much thyroid. Will Abaris decrease my TSH or can I take it with my current dose of Armour? I would like to lose about 10lbs that are stubborn but don't want to go hyperthyroid.
Dr. Walter Pierpaoli replies; " TRH may increase TSH levels but only in patients with low TSH pituitary function. However the activity of TRH is negligible and misleading because TRH does not interfere at all with thyroid function! TRH is an independent basic entity which helps to correct the whole deranged neuroendocrine-immune system in aging persons.
Our pharmacist adds; "obviously you should continue to monitor your thyroid dose. The simplest way to do this is to record your morning- rising from bed- body temperature. Keep a thermometer and a notepad and pen by your bed. If over the course of approximately 2 weeks your temperature is often above normal body temperature of 97.8 to 98.2 degrees Fahrenheit then you may need to adjust your thyroid dose downward. Of course, if it is often less than 97.8 degrees F, then the thyroid dose may need to be adjusted upward."
I am interested in TRH but want to check two things before I purchase, firstly is it Ok for people with Hypertension to take? And secondly is there an age limit for taking TRH?
There are no known contraindications between TRH and hypertension in normal dosing. There is also no known upper age limit with TRH, although the usual conditions of gradual dosing with older individuals, as per all drugs, are advisable. Of course if the patients are consuming other medications, changes may need to be made to their program. Naturally all of this is conditional on the advice of your own personal physician. We hope this helps.
I would like to know if TRH effects Prolactin levels?
Dr. Walter Pierpaoli has advised us that in the 23 years he has been researching and using TRH, that he has not seen any significant increases in prolactin levels in TRH patients. He goes on to say that there are published papers out there that may suggest that TRH may have some influence on prolactin, but that these are at very high dosage and when it is administered intravenously. Therefore, there is very little chance of such effects when used at 5 to 10mg daily sublingually.
I have been taking 150mcg of Syntheroid for 8 yrs . May I discontinue the Syntheroid when I receive my TRH shipment. I do not wish to feel hyper. I am 78 yrs. old and bicycle 3 miles every day. I am 6'2" weigh 200 lbs. and am on Benecar 20 mg per day blood pressure medication and do not wish to get blood pressure spikes from the combo of TRH and Syntheroid.
The use of TRH, as Dr. Pierpaoli has pointed out in his published papers and also in our recent interview with him - does not affect the thyroid gland as much as its name and reputation suggests. But none-the-less there can be improvements to the release of various thymus hormones with its use; unfortunately it is difficult to be precise and suggest to you that you will be able to discontinue Synthroid completely- there is a better chance that you will be able to reduce its dose however.
By the way, we have many supporting articles on our website about the use of natural thyroids vs. Synthroid® (T4) and you may want to look into these. In the vast majority of cases patients perform better on a natural thyroid like Armour® than on one of the synthetics- as you are taking. There are a number of reasons for this, not least of all that the natural thyroids contain all four thymus hormones including T3 and T4, including the ‘forgotten’ T1 and T2.
Obviously it will be in your interest to measure your heart rate and blood pressure, but the classic way to ensure that your thyroid is not overactive (or for that matter underactive) is to measure your rising from bed body temperature. Those details are contained within Dr. Ward Dean’s article here.