Human growth hormone (HGH) is produced naturally in our bodies, but the levels decline as we age. Since the 1980’s it has been possible to supplement using recombinant growth hormone to maintain youthful levels of HGH, resulting in numerous benefits to mind and body, but Human Growth Hormone can have a number of side effects if unmonitored and if it is taken in too great a quantity. But the disadvantages of HGH supplementation are a thing of the past with the development of sermorelin. Sermorelin is a small peptide molecule that stimulates the pituitary gland to produce and secrete human growth hormone naturally, rather than just adding from an external source.
HGH has the ability to reduce subcutaneous fat, which is the fat found just below the skin. It has also been clinically proven to increase lean muscle mass, enable faster repair to damaged parts of the body, increase stamina and promote a general increase in rate of metabolism.
By stimulating the pituitary gland, Sermorelin preserves more of the growth hormone neuroendocrine axis. This axis is the first to fail during the aging process and by preserving it, a more youthful outer-body and a youthful physiology can be attained.
Unlike Human Growth Hormone injections Sermorelin is easy to administer and can be stored at room temperature. A dropper full of Sermorelin each evening held under the tongue for 60 seconds before swallowing, is all that’s required.
Using sublingual Sermorelin gives the aging individual all the benefits of increased HGH levels such as reduced subcutaneous fat, increased muscle mass and increased stamina, but is simple to use and has none of the negative effects of simply supplementing with human growth hormone.
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Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical / published results.
Do you know of any studies demonstrating that sublingual administration of Sermorelin does produce higher levels of HGH?
A small study has been done but we are not yet allowed to release results pending its publication. Dr. Walker has talked about this subject in some detail however in his latest interview which is uploaded here.
As Sermorelin is 29 amino-acids doesn’t it have to be injected? Is it possible to transport anything across the cells with a molecular weight of 33358 moles?
The weight of a molecule is the sum of the weights of its atoms. The unit of such weight is called the dalton. Thus, the molecular weight (MW) of sermorelin is 33,358 daltons. A mole is the quantity of a substance whose weight in grams is equal to the molecular weight of the substance. In other words, a dalton is a measure of weight whereas a mole is a measure of quantity or amount.
Actually, Sermorelin when used clinically is technically a salt, not an amino-acid base. In fact it is the acetate salt of an amidated synthetic 29- amino acid peptide (GRF 1-29 NH 2) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone. An aminoacyl means the radical formed from an amino acid by removal of a hydroxyl (OH) moiety from a carboxyl (COOH) group. During peptide bonding these radicals are joined together, that’s how Sermorelin is synthesized.
As for transport, the chemists at Abbot Laboratories were awarded a US Patent in 1996 (5,487,898) for their work in moving large molecules via sublingual application. Now I realize that the patent is for oligopeptides, (small peptides containing mixtures of amino acids of twenty aminoacyl residues or less). So we're surprised to find out that the method works for some that are even a few residues larger such as sermorelin. This has been achieved with the sublingual Serm-Pro™ carriers- they are not just there as excipients.
Isn’t Sermorelin nothing more than cjc-1295 either a dac version or a non dac version, which when injected has a very short acting life of only 15 minutes?
Sermorelin is neither CJC-1295 nor its dac conjugated analog. Some companies are offering these analogues online for use via injection; presumably CJC-1295 is designed to be conjugated with albumin so as to extend its half-life, whereas dac is a molecular modification that extends half-life for several days. However, neither has been reported in the peer-reviewed, (legitimate, non-anecdotal literature) as being superior to Sermorelin for clinical application, nor as safe, i.e., lacking side-effects as Sermorelin does. Also, the relatively short half-life in the case of Sermorelin is irrelevant since the priming effect of daily dosing is cumulative, thereby increasing pituitary reserve and facilitating more youthful, spontaneous neurogenic secretory profiles that sustain muscle mass, decrease fat reserves and all the rest.
Do you know of any studies demonstrating that oral administration of Sermorelin does produce higher levels of HGH?
A small study has been done but we are not yet allowed to release results pending its publication. Dr. Walker has talked about this subject in some detail however in his latest interview which is uploaded here: http://www.antiaging-systems.com/articles/273-interview-with-dr-richard-walker.