Acomplia aka Zimulti - The latest breakthrough for obesity and smoking cessation

Acomplia / Zimulti contains Rimonabant, the long awaited breakthrough drug by Sanofi for the treatment of obesity and smoking cessation.

Acomplia represents one of the latest and indeed a most novel method for controlling body weight. Acomplia operates by being a cannabinoid receptor antagonist. This means that Acomplia prevents the normal action of endogenous cannabinoid in the brain from stimulating the so-called CB1 receptors. It would appear that these receptors stimulate appetite and therefore when they are “subdued” so is the need to eat.

The clinical trials that have been run over the past few years are impressive and have shown that these receptor sites may be responsible for more than just appetite, because the results show that Acomplia also aids people to stop smoking and even improves cardiovascular factors such as cholesterol ratios. With specific regard to weight loss, the human trials have shown an average weight loss of 10% of bodyweight, most importantly that weight has remained off even up to 2-years later. Also importantly, it would appear that the majority of weight is actually lost from the difficult to lose area around the waist. The average figures from the trials show a loss of fat of 20 lbs (9 Kg) and 3 inches (8 cm) diameter taken off the waist.

Additional trials have been undertaken to help smokers kick the habit. Even here Acomplia has been successful, showing that persons using Acomplia have double the chance of quitting smoking for good, and perhaps importantly also helping those smokers from not gaining any weight once they stop smoking, (as it is often the case that smokers trying to quit substitute their cigarettes with food etc.).

On top of that, Acomplia has also been shown to improve HDL (good cholesterol) and triglyceride levels, showing benefit for diabetes and heart conditions.

Meanwhile, Acomplia has shown few and minor side effects in the clinical trials, some of which have been conducted continuously for 2-years. Side effects noted in the studies were mainly mild and transient consisting (in order of frequency) of nausea, dizziness, diarrhoea, vomiting, hypoglycaemia and anxiety. The most beneficial doses noted in the trials have been 20 mg. daily. Perhaps it is no wonder that Acomplia is expected to be a blockbuster drug now it is available in Europe.

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Acarbose – effective treatment for diabetes and weight loss

Acarbose has a unique mechanism of action in that it reduces blood sugar peaks and slows the absorption of glucose in our bodies. This reduces food cravings and makes Acarbose an ideal drug for diabetics or anyone wanting to loose weight.  Acarbose has a different mechanism of action to loperamide, which addresses conditions associated with diarrhoea.

Acarbose helps lower the risk of kidney failure and heart disease associated with high blood glucose levels. Taken daily, regular acarbose dosage provides a more stable supply of essential blood sugars. This mechanism of action ensures you feel full for longer, and counters the damage caused by excessive insulin. Put simply, Acarbose allows diabetes sufferers to live more normal lives.

ACARBOSE / GLUCOBAY ®

Tablets, each containing 50 mg acarbose. The tablets also contain  starch, cellulose, magnesium stearate and silicon dioxide. Glucobay 50  comes in packs of 90 tablets. Glucobay 50 contains acarbose which is one  of a group of substances known as glucosidase inhibitors which are used  to treat diabetes.

Why have I been prescribed Glucobay 50 by my doctor?
This  medicine has been prescribed for you by your doctor to treat your  diabetes. Glucobay will help to control your blood sugar levels. This is  because Glucobay works by slowing down the digestion of carbohydrates  (complex sugars) from your diet, and this reduces the abnormally high  blood sugar levels that occur after each meal.

When should I not take Glucobay?
Do not take this medicine  if you have previously had an allergic reaction to any of the  ingredients. If you are unsure about this ask your doctor. Do not take  this medicine if you are under 12 years of age. Do not take this  medicine if you are pregnant or breast-feeding. If you are taking  Glucobay and think that you may be pregnant, or are planning a family,  consult your doctor. You should not take Glucobay if you have any of the  following medical conditions:

    • If you suffer from inflammation or ulceration of the bowel, e.g. ulcerative colitis or Crohn's disease.

    • If you have, or are susceptible to, an obstruction in your intestines

    • If you have a liver disorder.

    • If you have an intestinal disease whereby you do not digest or absorb food properly.

    • If you have a large hernia or any other condition where increased gas in your intestine may make it worse.

    • If you have a kidney disorder do not take Glucobay without consulting your doctor first.

    • If you are unsure whether you might have any of these conditions, please ask your doctor.

What special precautions should I take?
Treating  hypoglycemic episodes ("hypos"). As a diabetic you may also be receiving  other treatments for your diabetes. If you are taking insulin or  sulphonylurea drugs to control your blood sugar, you will probably be  used to avoiding hypoglycemic episodes by taking sugar when you feel  that your blood sugar level is too low.
WHEN TAKING GLUCOBAY DO NOT  TREAT A HYPOGLYCAEMIC EPISODE WITH ORDINARY SUGAR (SUCROSE). INSTEAD  TAKE SOME GLUCOSE (ALSO KNOWN AS DEXTROSE) TABLETS, SYRUP, OR SWEETS  WHICH SHOULD BE AVAILABLE FROM YOUR LOCAL PHAR- MACIST.
This medicine  may affect the levels of certain proteins called enzymes in your blood.  Your doctor may wish to see you more frequently in order to monitor the  levels of these enzymes. Glucobay may alter the effect of other drugs  or, alternatively, some drugs may alter the effect of Glucobay. If you  are using any of the following drugs, speak to your doctor or pharmacist  before taking this medicine:
-Drugs known as intestinal adsorbents e.g. charcoal.

    • Drugs to help your digestion (digestive enzyme preparations).

    • The antibiotic, neomycin.

    • Cholestyramine, a drug used to treat high cholesterol.

When and how do I take Glucobay?
To gain the maximum  benefit from Glucobay you should adhere to the diet prescribed for you  by your doctor. This will also help in reducing any side effects you may  experience. Take the tablets as prescribed by your doctor. This will  normally be one or two tablets taken with meals three times a day.  However, when you first start your treatment, your doctor may recommend  that you take your tablets once or twice a day before increasing your  dose to three times a day. This medicine is intended for long-term use.  Glucobay tablets should be chewed with the first mouthful of food. If  you prefer not to chew the tablets then swallow them whole with a little  liquid immediately before the meal-
DO NOT EXCEED THE PRESCRIBED DOSE.
If  you do exceed the prescribed dose, or in the event of an overdose, you  may experience diarrhea and other intestinal symptoms such as flatulence  (wind) and abdominal pain. If you take more than the prescribed dose,  or in the event of an overdose, avoid the intake of carbohydrate  containing food or drinks and seek medical advice immediately. If  possible, take your tablets or the pack with you to show the doctor.

What should I do if I miss one or more doses?
If you forget  to take one or more doses of Glucobay do not take the tablets between  meals but in- stead, wait until your next scheduled dose and meal and  continue as before.

What undesirable effects may I experience?
During the first  few days or weeks of treatment with Glucobay you may experience  increased flatulence (wind), rumbling in your stomach, a feeling of  fullness and possibly abdominal cramps. It is also possible that you may  pass softer stools or even experience diarrhea, particularly after a  meal containing sugar or sucrose containing foods. Normally, these  symptoms will disappear if you continue treatment and keep to your  prescribed diet.

DO NOT TAKE INDIGESTION (ANTACID) PREPARATIONS FOR TREATING THESE  SYMPTOMS, AS THEY ARE UNLIKELY TO HAVE ANY BENEFICIAL EFFECT. IF YOUR  SYMPTOMS PERSIST FOR MORE THAN 2 OR 3 DAYS, OR IF THEY ARE SEVERE,  CONSULT YOUR DOCTOR, PARTICULARLY IN THE CASE OF DIARRHOEA.

Less common side effects include inflammation of the liver  (hepatitis), jaundice (yellowing of the skin) and skin reactions such as  redness, rash and urticaria (hives). Glucobay tablets may cause an  increase in the levels of certain proteins called enzymes in your blood.  These effects go away when treatment is stopped.

IF YOU EXPERIENCE ANY UNDESIRABLE EFFECTS, TELL YOUR DOCTOR IMMEDIATELY. YOUR DOCTOR WILL GIVE YOU ADVICE.

How should I store my Glucobay tablets?
It is best if you  keep your tablets in the original carton supplied. The tablets should be  kept in a dry place where the temperature is not likely to exceed 25°C.  KEEP OUT OF THE REACH OF CHILDREN. Do not use tablets beyond the expiry  date that is marked on both the outer container and on each blister  strip of tablets. If you find that you have tablets after their expiry  date, return them to your local pharmacist who will dispose of them  properly.

REMEMBER: THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. DO NOT  GIVE IT TO ANYONE ELSE UNDER ANY CIRCUMSTANCES. IF YOU HAVE ANY DOUBTS  ABOUT TAKING GLUCOBAY CORRECTLY SEEK THE ADVICE OF YOUR DOCTOR.
Date of Preparation: February 1999
Product License Number: PL 0010/0171


The above  information is the translation of the manufacturer's insert. It is  provided under the supplying company's terms and conditions and should  not replace the advice of your personal physician.

MADE IN EU

MILGAMMA ® MONO 50

Ingredients:
50.0 mg Benfotiamin per tablet

Ingredients:
Corn starch, talc, magnesium stearate, polyvinol K25, Arabic gum, titanium dioxide (E171), glucose syrup, white clay, macrogol 6000, carboxymethyl cellulose sodium, magrogol glycerolhydroxystearat, calcium carbonate, natriumdodecylsulphate, montanglycolwachs

  • Does not contain lactose

Description:
Milgamma ® mono 50 is used to prevent and treat Vitamin B1 deficiencies if it was not possible to remove this deficiency through nutrition. For example:
1) Poor nutrition

  • Diet and fasting
  • Unbalanced nutrition (e.g. Wernicke's disease, alcoholic cardiomyopathy
  • Malabsorption
  • Parenteral nutrition

2) Increased need
3) Hemodialysis

Side effects:
Do not use milgamma ® mono 50 if you are hypersensitive towards Benfotiamin or thiamine. In special cases the patient can show a hypersensitive reaction (skin rash, nettle rush). If you show symptoms of any side effects stop using this product and contact your doctor.

Use during pregnancy and nursing:
This medicine is to be used during pregnancy and nursing only for a measured serious Vitamin B1deficiency and should be stopped as soon as the Vitamin B level is back to normal.

Dosage:
If no other regimen is recommended by the attending doctor,

  • 1-2 tablets weekly as prevention
  • 1-3 tablet daily as treatment

To be swallowed whole with a small volume of water.


The above information is the translation of the manufacturer's insert. It is provided under the supplying company's terms and conditions and should not replace the advice of your personal physician.

MADE IN EU

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