Pyridoxamine – the rarest and most potent Vitamin B6

We all know the importance of supplementing our diet with vitamin b 6 for our general health and wellbeing, but the benefits of vitamin b6 in antiaging are perhaps less documented, yet equally crucial.

Pyridoxamine is one of three natural compounds that make up vitamin b6, the other two being pyridoxal and pyridoxine hcl. All three of these vitamin b6 compounds are important to us for the proper functioning of our nervous system and our immune system. We need Vitamin b6 to help us combat stress and give us energy.

These three key vitamin b6 compounds – pyridoxal, pyridoxine and pyridoxamine - are converted in the body into the biologically active form of vitamin b6 called pyridoxal 5 phosphate and are used in different ways.

The least commonly available vitamin b 6, Pyridoxamine is the most potent of the three, and it also happens to be the most effective in antiaging terms.

Clinical trials have revealed that one of the most important features of Pyridoxamine is its ability to inhibit a process known as glycosylation. Glycosylation occurs when sugar meets oxygen and protein, thereby inhibiting the proteins from going about their important functions.

Glycosylation is responsible for aging disorders such as cataracts, hardened skin and tough collagen, plus it’s a prominent feature of diabetes. The benefits of pyridoxamine over other vitamin b6 supplements are that it’s able to slow down the glycosylation process. This makes pyridoxamine a powerful weapon in the antiaging war.

Pyridoxamine benefits

Vitamin b6 is available in three naturally occurring forms: pyridoxal, pyridoxine hcl and pyridoxamine. Pyridoxine is the most commonly found in vitamin b6 supplements, however all three forms have antiaging properties.

Pyridoxal 5 phosphate and pyridoxamine 5 phosphate (PMP) are the active coenzyme forms. Pyridoxine is found in plant sources, whereas pyridoxamine and pyridoxal are both derived from animal sources.

All three vitamin b6 forms – pyridoxamine, pyridoxal and pyridoxine – are converted in the human body into the single biologically active form, pyridoxal 5 phosphate. Pyridoxal phosphate deficiency can lead to serious complications such as epilepsy and seizures, so taking pyridoxal 5 Vitamin b 6 is highly beneficial.

Pyridoxamine reviews suggest it might also be helpful in improving kidney disorders and in preventing kidney stones.

Pyridoxamine effects

Of all the three naturally occurring forums of vitamin b6 – pyridoxamine, pyridoxal and pyridoxine – pyridoxamine has the most potent antiaging properties.

One of the most noticeable Pyridoxamine features is its ability to prevent the formation of Advanced Glycated End products (AGES) that have long been associated with aging.

Advanced Glycated End products are large insoluble aggregates of damaged proteins in the tissues – the results of gycosylation or cross-linking. Once formed, AGES stimulate cells to produce more free radicals, such as superoxide and nitric oxide, and activate pro-inflammatory substances in the immune system.

There are a variety of chronic and age-related diseases associated with the accumulation of AGEs in tissues and organs. AGES are known to increase the risk of cancer and degenerative diseases. Cross-linking also contributes significantly to diabetic complications, and can cause cataracts, kidney damage, skin ageing and other age-related diseases.

There are a number of stages in the formation of AGES. While anti-glycators such as Aminoguanidine are excellent at preventing early-stage glycation, pyridoxamine has been proven to be the most effective in the later stages.

Pyridoxamine works both by inhibiting the formation of AGES and ‘trapping’ advanced lipoxidation end-products (ALEs). The presence of ALEs may affect the function and integrity of the vascular wall, leading to atherosclerosis. Pyridoxamine may also, therefore help prevent potential heart disease.

Recommended dosage of Pyridoxamine

The recommended dosage of pyridoxamine is 50mg once daily. For people suffering from pyridoxal phosphate deficiency, higher dosages of B6 pyridoxal may be recommended.

As we have seen, pyridoxamine is the rarest and most potent of all three naturally occurring forms of vitamin b6 in the war against aging. Supporting healthy nerve, eye, cardiovascular and kidney function, pyridoxamine may be the key to a healthy, long life.



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