My patient, Mona, breezed into my office with a desperate look on her beautiful face. In a hurried and flustered manner, she explained that aging was playing havoc with her skin. In spite of using umpteen lotions and cosmetic creams, her fine lines and crevasses were becoming a permanent fixture on the landscape of her face. Her muscles were becoming droopy, and her thinking was less than clear and creative compared to years ago.
“Oh, dear,” she exclaimed, “Why is Mother Nature playing dirty tricks on me?” Before I could respond to her question, she asked, “Why don’t those $180 creams from eminent dermatologists work anymore?”
“Give me a minute to explain,” I responded. I began by saying that I had worked with cosmetic chemists decades ago when Gail Hayman of Beverly Hills, the noted inventor of Giorgio’s™ perfume, asked me to assemble a team of chemists and dermatologists. She wanted to create a new Giorgio’s™ 122-cosmetic products line and extend the marketing success of the Giorgio brand. I discovered that many cosmetics do work, but only in a limited and temporary way in correcting the signs of aging. Since then, physicians specializing in anti-aging have learned quite a bit more about how we age and what to do about it. Cosmetics might be great for covering up or pulling tight the signs of aging, but my colleague physicians specializing in anti-aging and I can do a lot more about aging today, whereas in years past it was only a pipe-dream. Cosmetics and face-lifts can become unnecessary if one becomes knowledgeable in the emerging medical specialty of ‘anti-aging’ or ‘age management’ medicine. I reassured her that not only could I tighten up her face, but I could create a major improvement in her quality of life, health, and general physical appearance.
Years ago, scientists only understood a ‘Band-Aid™’ approach to aging. In other words, we could temporarily and superficially fix only symptoms of aging, but the underlying causes of aging were largely unknown. Today, on the other hand, I can say with conviction that many of the underlying causes of aging are known, and remedies are at hand for a wide variety of aging problems and diseases, such as failing memories, slower information processing, shrinking organs, crepe-paper skin, and cardiovascular problems.
Indeed, some brilliant scientists, such as Dr. Ray Kurzweil at Stanford University, have suggested that we should be readying ourselves for the eventual arrival of the ‘Singularity’ within the next twenty years (‘Singularity’ refers to a time in human history when all major diseases become curable and mankind attains immortality with the exceptions of accidental or suicidal deaths*).
*Side note: Dr. Kevorkian died at age 83, and his last words were “Isn’t there someone around to help me?”
Mona paused and stared at me in disbelief. After a few silent minutes, she stumbled with her words and asked me to continue. I said that instead of giving her a four-hour tutorial lecture, I would prefer that she read my new book, entitled Stay 40¹, and get back to me with questions. She collected her thoughts and said in passing that she would read my book and schedule a future visit.
The New Paradigm: A Simple Fact about Aging Finally Discovered
During the last five years, more progressive U.S. medical schools have begun to teach courses in the new specialty called ‘anti-aging’ or ‘age management’ medicine. These new courses are grounded upon one simple and new premise:
Human aging is largely caused by hormone imbalances and failing nutritional support.¹
Before this new paradigm of thinking was introduced and generally accepted, many scientists believed that we wear out as we age, much like a phonograph needle eventually scratches and wears out a vinyl-plastic phonograph record. Advanced medical research has determined, however, that we do not wear out. Instead, our hormones become deficient due to shrinking endocrine (hormone) glands and damaging poisons from the environment, such as mercury and PCB insecticide.
Secondly, these defects cascade in the digestive cells of our gastrointestinal (GI) tracts. Thus, these sensitive cells eventually restrict access to critical vitamins and nutrients essential to our health and longevity. For example, after approximately ages 45 to 55, the body no longer processes and absorbs vitamin B12 in the ileum (small intestine), since ileum cells have lost a vital co-factor necessary for B12 absorption.
Also, in this same age range, the liver progressively reduces production of the body’s most critical repair polypeptide, IGF-1, since liver cells no longer respond to pituitary signals mediated by human growth hormone (HGH).
Thirdly, in this approximate age range, our hair progressively loses its pigmentation and turns grey or white due to deficiencies of melanocyte-stimulating hormone (MSH) and B vitamins.²
Fourthly, and worst of all, we all suffer from progressively unseen and undetected damages to our DNA. Free radicals cause damage to DNA at the approximate rate of seven thousand hits per day. Also, we have no enzyme defenses against the most chemically reactive free radical of all, the hydroxyl radical, symbol •OH.
Our only defense against the hydroxyl radical is high concentrations of the powerful antioxidant, l-glutathione, which becomes increasingly deficient as the growth hormone and IGF-1 become increasingly deficient.¹ Thus, during aging, these two critical substances decrease while hydroxyl radicals and damages to DNA increase. Young people have sufficient growth hormone and IGF-1 to repair these critical damages, but older folks are progressively lacking them. They must supplement them if they wish to stay youthful and healthy (thus, my book’s title, Stay 40).
All of the above factors play havoc with our health. Consequently, the average 65-year-old American suffers from approximately five diagnosed or undiagnosed diseases that require between nine and twenty drugs daily with consequent adverse side effects! Then, the pharmaceutical industry chocks up billion-dollar profits, which are paid for by a progressively bankrupt Medicare system!
Indeed, this new paradigm of anti-aging medicine has prompted some experienced physicians at America’s leading hospitals to state emphatically that Americans could be much healthier and Medicare costs reduced by at least a third if this new paradigm were adopted. However, given the hundreds of billions of dollars in profits generated by the existing system, its adoption is unlikely in the foreseeable future.
Hormone Correction Improves and Reverses Many Aspects of Aging, Especially in Seniors
During the last five years, primarily in Belgium and the USA, physicians specializing in anti-aging have become active in slowing or reversing aging in those patients desiring more than Medicare (or, as I prefer to call it, “Mediocre-care”) currently provides. Their methods have nothing to do with cosmetics or dermatological treatments. Indeed, several physicians of my acquaintance have even specialized in patients over the age of 80, since current treatment often abandons them or prescribes drugs not tested on the elderly. These forward-thinking physicians start slowly by correcting for nutritional, or nutraceutical, deficiencies, such as the supplementation of a daily tablet of sublingual vitamin B12 and ubiquinol (a reduced formed of CoQ10 taken 100mg daily). Only sublingual B12 helps to regain or enhance muscle and neurological control. Ubiquinol is a key nutraceutical for preventing heart problems, and patients are often lacking it when taking synthetic drugs, especially the ever-popular statin medications.
These forward-thinking physicians monitor their senior patients extensively with frequent referrals to other medical specialists. They start them on a mild exercise program, such as kicking one’s legs in a swimming pool for at least an hour daily. Eventually, after evaluating and monitoring test results, they began to treat them with very low doses of hormones, such as natural desiccated thyroid (See ERFA Thyroid Natural® or Armour® starting with a quarter grain daily) and liposomal testosterone cream (often a 50mg daily starting dose for men or a 3mg daily starting dose for women; a starting dose of 150-mg or more is totally unwarranted, especially in seniors). In both men and women, this last hormone is merited due to the fact that 100-year-old Okinawan women (the oldest living people on the planet) have, on average, more than double the amount of testosterone than 70-year-old American women. Secondly, the faculty of the Harvard Medical School has given its stamp of approval to its professor, Abraham Morgentaler, and his new book, Testosterone for Life,³ as the new health standard, even for men with existing prostate cancer! (Another vital hormone often slated for correction in seniors is DHEA (dehydroepiandrosterone).
Physicians specializing in anti-aging have learned to slowly step-up monthly hormone dosages in older patients, while carefully monitoring them to improve their health and help them regain mental and physical functions. Side effects may occur only when patients overdose, or if dosage is increased too rapidly.
Daily Dosing with the IGF-1/ HGH Cocktail
Eventually, after several months, patients advance to the final step with HGH and IGF-1 therapy. This step is the most powerful tool that anti-aging medicine has to offer, namely a twice-daily cocktail of human growth hormone (HGH) combined with the polypeptide, IGF-1. However, please keep in mind that this cocktail will only work if supported by;
(A) Sufficient anabolic hormones, such as testosterone, DHEA, estradiol, etc., and
(B) Sufficient thyroid (T3 and T4) and cortisone
(C) Sufficient protein and amino acids. All of these components plus
(D) Regular exercise contributes to prevent the body from deteriorating, and they build the body up physically and mentally.
A junk food diet will not work. Please keep in mind that during aging, shrinking, wrinkling, and wasting are caused by lack of A, B, C and D.
This final treatment employs IGF-1, which must be stepped up gradually, starting with 0.01mg every other day, and ending with a maintenance dose of 0.10mg daily after approximately two and a half months. I describe the exact step-up procedure as follows.
Every ten days, increase dosage starting with:
- 0.01mg once a day and injected only every other day for the first ten days.
- For the second ten-day period, inject 0.005mg twice daily during mornings and before bedtime.
- For the third ten-day period, inject 0.01mg twice daily.
- For the fourth ten-day period, inject 0.02mg twice daily.
- For the fifth ten-day period, inject 0.03mg twice daily.
- For the sixth ten-day period, inject 0.04mg twice daily.
- For the seventh ten-day period, inject 0.05mg twice daily. This is the maintenance dose totaling 0.1mg daily. Further increases may be warranted according to benefits, signs, and symptoms as listed at the end of this paper. Patients should watch for overdose signs and report them to a knowledgeable physician specializing in anti-aging or age management medicine.
- Physical Appearance: The cocktail may improve and greatly reduce wrinkles and the saggingand atrophying of the body.
- Organ Function: The cocktail allows people to maintain excellent health by improving and repairing muscles and inner organs, including the brain, heart, kidneys, joints, lungs, and nerves.
- Repair Systems: The cocktail reduces cellular damages and accelerates cellular repair.
- Free Radical Formation: The cocktail stimulates antioxidant activity, especially l-glutathione, and limits excessive free radical formation.
- Emotional Improvement: The cocktail promotes increased inner peace, psychic well-being, self-assurance, leadership, self-confidence (especially combined with oxytocin), problem solving, and reduced stress.
- Improvement in elevated glucose and insulin: The cocktail benefits those with both Type I and II diabetes and lowers risk for both hypoglycemia and increased body fat. It also increases lean muscle mass.
- Improvement in immune defenses.
- Inhibits undesirable apoptosis and limits healthy cell proliferation.
- Telomere Length: A reduced serum IGF-1 correlates with reduced telomere length.
- Degradation of physical appearance, premature aging, and severely impaired quality of life.
- Obesity, droopy muscles, droopy eyelids, thinner lips, thinner jaw bones, thinner eyebrows, thinner nose (tip pointed downward), thinner skin, and droopy abdomen with stretch marks.
- Bowed back (thoracic kyphosis) and excessively curved lumbar back (hyperlordosis).
- Atrophy of the jaws, nose, chin, ears, hands (atrophic metacarpal bones), feet, bones, genitals, nails (as evidenced by longitudinal lines), sagging cheeks, and loose skin folds under the chin.
- Sore feet after long walks, fallen arches, atrophied soles of the feet, flat feet, and sagging inner thighs.
- Energy compromised as evidenced by exhaustion with little or no recovery.
- Energy compromised by feelings of deep physical degradation.
- Poor stress tolerance.
- Great difficulty multitasking due to lack of concentration or feeling powerless.
- Low self-esteem and lack of self-confidence.
- Chronic anxiety, lack of inner peace, and a tendency to become easily depressed.
- Irregular sleeping habits.
The average dose for adults with mild deficiency is 0.2 mg daily; however lower IGF-1 doses prescribed here are sufficient when combined with 0.08mg HGH daily. I label this my ‘IGF-1/HGH cocktail.’ In other words, growth hormone should be added to this twice-daily mixture at a dosage of approximately one-fourth of a unit HGH (0.04mg twice daily). Typically, I mix both HGH and IGF-1 in a BD 31 gauge insulin syringe that is sufficient for three or four injections. In between injections, I store the syringe in the refrigerator along with my ampoules of HGH and IGF-1.
(Note that liquid solutions of IGF-1 but not HGH will deteriorate if left unrefrigerated. Also, it is advisable to dissolve IGF-1 in isotonic water containing 0.6% acetic acid. The acetic acid balances the pH at about 4.5 and protonates the polypeptide IGF-1 molecule for optimal effect.)
General Benefits of the HGH/IGF-1 Cocktail
I usually notice benefits from the cocktail after approximately the second or third month. First, I observe that brain processing speed increases significantly; 65-year-olds begin to show information processing speeds typical of younger people. For example, I and others over age 50 have reacted faster in emergency traffic situations that require quick thinking and physical dexterity behind the wheel. In other words, one reacts faster to ambulances and fire trucks than other drivers.
Secondly, I have become a strong sprinter, powered by balanced nutrients and hormones, especially the HGH plus IGF-1 cocktail. One day, I tied my powerful Airedale terrier, Maggie, to a wooden chair at the Whole Foods™ market. Soon afterwards, Maggie became frightened and took off running with the chair dragging behind her. Then, two young Whole Foods™ employees ran after the market’s vanishing chair. The dog and chair disappeared to a distant parking lot. In a panic, I ran full-speed after the dog and chair, and I quickly passed the two huffing and puffing twenty-somethings and caught up with the escaping Maggie. The winded and exhausted Whole Foods™ youngsters commented that I must be a marathon runner, which I definitely am not (I am a somewhat lethargic scientist)! This remarkable cocktail returned to me my physical and mental agility, presumably lost many decades ago.
Specific Benefits of the HGH/IGF-1 Cocktail
However, please note carefully that I could not just start off on the cocktail without other supporting hormones and nutrients. All of these components work in synergy with one another and allow the body and mind to multitask with the environment. As Dr. Thierry Hertoghe often says, hormones and nutrients must be well-balanced if one wants to escape many of the ravages of aging. In his Hormone Handbook, Vol.2,² he states specifically the following as improvements with the HGH/IGF-1 cocktail, if other hormones and nutraceuticals are first balanced:
Signs and Symptoms of Aging Identified
According to Dr. Hertoghe and me, many of the following signs and symptoms of aging are often helped with the cocktail, assuming all other hormones and nutritional deficiencies are first addressed, which are as follows:
The HGH/IGF-1 cocktail may sound like a new fountain of youth, but this view is unfortunately incorrect. The cocktail is merely one major step forward in avoiding many of the ravages of aging and in enhancing health, especially in people over the age of 50. The cocktail is the here-and-now, cutting-edge solution to slowing and reversing aging while we await developments in gene therapy that promise to correct and renew our aging bodies at the genetic level (in other words, the altering and reprogramming of our epigenome).
(1) Richard, Lippman, Stay 40, Outskirts Press Inc., Denver, CO, 2009.
(2) Thierry Hertoghe, The Hormone Handbook Vol.2, Medical Pub Surrey, ENG , 2010 International
(3) Abraham Morgentaler, Testosterone for Life, McGraw Hill, New York, 2009.
The author thankfully acknowledges the valuable advice and calculations of Russell Laudon, MD used in the preparation of this paper.