AMPK (activated protein kinase) is an enzyme present in all mammals – it is activated during exercise to help restore energy and balance nutrient supply as the body demands them. If AMPK levels become defective, this can lead to issues with energy production, glucose uptake and muscle strength.
Metformin is well known to aid AMPK activation and promote glucose uptake – this is why it is recommended as a supplement to help AMPK remain at optimum levels.