A natural substance produced by the pituitary gland in the brain, HGH controls muscle and bone growth and reduces the amount of fat circulating in the body. Again, combined with exercise it causes muscle growth.
Often abbreviated to HGH, this hormone as its name suggests it is responsible for growth during puberty. The remarkable clinical action of HGH has meant it is now a front line treatment in the battle against aging. This is because HGH levels dramatically decline in aging. Look at the chart to see a figure depicting the decline of HGH levels with advancing age.
Dr. Daniel Rudman discovered in 1988 that when HGH was administered to his elderly patients, that within several weeks they all noticed significant improvement. The benefits included enhanced well being, lessened depression and over a few months noted increased skin thickness and improved elasticity, as well as a decline in fat cells and an increase in lean muscle mass.
Since then HGH manufacture has improved and expanded to enable a significant decrease in cost, although it still remains "not cheap." The correct chain length of this amino acid is 191 and it is ONLY effective when taken as a subcutaneous injection.
Your physician's guidance and blood monitoring is essential on a program of hGH, and as usual amounts of this hormone are highest in our early twenties and decline rapidly as we age. Physicians administering HGH for preventative/ anti-aging purposes utilize in the region of 0.01mg to 0.02mg of HGH per Kg of body weight (that's 2.2 lbs.) per week. This is injected subcutaneously (just under the skin) divided into 3 to 5 injections per week.
Although the precise protocol has not been confirmed, most of the physicians we deal with adopt this type of program. However, it is important to ensure that blood levels of HGH are monitored before and during the program and that a full check-up by an Anti-Aging Physician is performed before the course of HGH injections begin. If you need to find an Anti-Aging Physician in your area, we will be pleased to help.
Human growth hormone supplements decline in frequency and sometimes stop for a period once the patient has reached a IGF1 blood plasma test equivalent to that of a 21 to 31 year old, again physicians differ on the line, some advocate early twenties, others early thirties measures.
We are now providing the Serono Human Growth Hormone called Saizen ®. This product has some advantages in shipping. Firstly it is stable at room temperature (before the product is constituted), and it also lasts longer once constituted (when it has to then be kept in a fridge). Once constituted, the product should be discarded after 30 days.
The information below is the translation of the manufacturer's insert. It is provided under the supplying company's terms and conditions and should not replace the advice of your personal physician.
SAIZEN ® 1.33 mg
The ampoule bottle with lyophilised powder contains: Somatropin .........1.33 mg equivalent to ......... 4 IU Excipient ......... s.q. The small ampoule of diluting agent contains: 0.9% sodium chloride solution .........1 ml
Properties:
The main active ingredient of Saizen ® is Somatropin, a biosynthetic human growth hormone produced from mammal cells through genetic engineering. It contains 191 amino acids, in identical sequence to that of the natural hypophysiary hormone. Saizen ® brings about an increase in the average growth rate by means of Somamedins or growth factors similar to insulin.
Contraindications:
Individual hypersensitivity to the active component in the product. Diabetes mellitus must be considered as a relative contraindication. In subjects suffering from diabetes mellitus, treatment should be carried out under strict medical and laboratory supervision. Saizen ® must not be used when there are progression data of a concomitant cerebral tumour.
Adverse side effects
Pharmacokinetic and toxicological studies carried out with Saizen ® and pit-hGH have confirmed that the safety of the recombinant product is similar to that of the natural growth hormone, with no side effects produced by the drug itself. However, treatment with human proteins can cause reactions as a result of hypersensitivity (such as redness and itchiness in the area of the injection site), the formation of antibodies with or without the attenuating effect of growth, or both.
In a small number of patients, where short stature is due to a genetic defect (depletion of the gene complex for hGH), Somatropin treatment can stimulate the production of antibodies which attenuate growth in the majority of cases.
Precautions:
Treatment must be carried out under strict periodic medical supervision. Patients with a deficiency of the growth hormone secondary to an intracraneal lesion should be examined frequently in order to follow the progression or recurrence of the underlying pathological process. Administering Saizen ® subcutaneously in the same site over a prolonged period of time may cause lipoatrophy. This can be prevented if the injection site is changed each time.
Drug interactions:
Concomitant therapy with corticoids may inhibit the growth promoting effect of Somatropin.
Directions for use:
Saizen ® can be administered intramuscularly or subcutaneously, preferably at bedtime. The contents of one ampoule bottle must be reconstituted with the diluting agent, by inserting the liquid into the ampoule bottle and gently shaking it until it is completely dissolved. Do not shake it vigorously, as this can cause a slight darkening of the solution.
Administration method:
Saizen ® can be administered intramuscularly or subcutaneously, preferably at bedtime. The dosage and method for administering Saizen ® must be adapted to the needs of each patient.
Dosage: Follow your doctor's instructions
Store in the refrigerator at 2ºC to 8ºC. Do not freeze. Do not use if the seal has been broken. Do not use after the expiry date. Once the mixture has been made, the product can be stored in the refrigerator at 2ºC - 8ºC.
Presentation:
Box with 1 ampoule bottle with lyophilised powder, 1.33 mg equivalent to 4 IU, and 1 small ampoule with 1 ml of diluting agent.
