Articles by KYRIAZIS, M.D., Marios


  • AMPK: a complicated metabolic signalling pathway

    Cellular homoeostasis is a crucial prerequisite for health and good function. Although the study of all the mechanisms involved in maintaining homoeostasis is extremely complicated and confusing, it is nevertheless possible to examine certain processes which play an important role in the orchestration of events designed to maintain efficient cell function. One such process is the role of AMPK (5' adenosine monophosphate-activated protein kinase), an enzyme which is present both in lower (yeas...
  • Methylation and Methylators

    As we interact with our environment, there are definite changes in our epigenetic profile. This means that information from our surroundings (such as interactions with society and culture, use of internet, communication with people, reading etc.) is reflected on how our genes are ultimately expressed. Monozygotic (identical) twins who have been exposed to different environments have different epigenetic characteristics (1). Information from the environment has an impact on DNA methyla...
  • The Role of Glycation in Aging

    Even people who have no training in chemistry or biology, but who are interested in the aging process, have heard of the Maillard reaction. This is a chemical reaction between proteins (specifically, amino acids) and sugar molecules, a process called glycation. The reaction was described for the first time in 1912, and it takes its name from the French chemist Louis-Camille Maillard. Over the years, this reaction has been studied in detail. Among other things, it plays a crucial role du...
  • NAD (Nicotinamide Adenine Dinucleotide) A versatile but complicated molecule

    NAD (Nicotinamide Adenine Dinucleotide): A versatile but complicated moleculeBy Marios Kyriazis, M.D. Reactive oxygen species (ROS) have been implicated in the pathogenesis of many age-related diseases such as diabetes, inflammation, neurodegeneration and cancer. Therefore, it stands to reason that if there is a way to control excessive production of ROS, then it is likely that the impact of such diseases will lessen. One particular compound which may be rele...
  • Why Do Women Live Longer Than Men?

    It is a known fact that, in general, women live longer than men. All life expectancy calculations over the past years tend to show that females live several years longer compared to males, as a group (see figure 1).   There are several theories trying to explain this phenomenon and some concepts are better supported by research than others. This discussion refers to the rate of aging process in regard to gender and not to the individual perception of aging. In other words, it...
  • Methylation and Methylators

    As we interact with our environment, there are definite changes in our epigenetic profile. This means that information from our surroundings, (such as interactions with society and culture, the use of internet, communication with people, reading etc.) is reflected on how our genes are ultimately expressed. Researchers have shown that monozygotic (identical) twins who have been exposed to different environments have different epigenetic characteristics (1).   What happens is t...
  • Telomerase Modulators

    It is true to say that telomeres and telomerase are one of the hottest areas of anti-aging research, but it is also true that the misconceptions and confusion in this area are significant. Here, I will assume that you are already familiar with telomeres and the general function of telomerase. In any case, I will discuss the supplements, nutrients and strategies that can help improve the overall function of telomerase and so result in healthy telomeres, and thus, healthy DNA. This coul...
  • Attention Deficit Hyperactivity Disorder

    Attention Deficit Hyperactivity Disorder By Marios Kyriazis, M.D.   One of the most controversial syndromes of modern times is what we now call ‘Attention Deficit Hyperactivity Disorder’ (ADHD). This is a behavioural condition which has implications well beyond behaviour. As its name suggests, the condition includes being hyperactive, restless and fidgety, with a short attention span, as well being impulsive, anxious, a bad sleeper and experiencing ‘lea...
  • Apoptotic Modulators

    Apoptotic Modulators Marios Kyriazis MD Apoptosis (a Greek word, meaning ‘falling off’) is a crucial event during aging. It is the orderly death of cells which are no longer functional or which are beyond repair. Apoptosis (also called ‘programmed cell death’) was first described in 1972 by Kerr, Wyllie and Currie (1) and it has been attracting substantial research interest since. The reason is that a better understanding of apoptosis ...
  • Updating the Calorie Restriction Mimetics

    Updating the Calorie Restriction Mimetics When I first started writing about Calorie Restriction Mimetics (CRM) 10 years ago, research in this area was at its infancy. Now however, several CRM are well-known and relatively well-accepted agents which imitate the effects of calorie restriction itself. I highlight the fact that these compounds are not merely pills for those who are too lazy to diet, but may be used (under medical supervision) in association with a healthy lifestyle to ...
  • Exercise Mimetics

    Exercise Mimetics By Marios Kyriazis MD Research into calorie restriction mimetics (drugs which mimic the physiological actions of calorie restriction itself) has opened up interest in other areas, where drugs or compounds may be able to afford the same benefits as the physical action itself. Here, by ‘action’ I mean not only diet, but also exercise or even sex! In a previous IAS publication I discussed calorie restriction mimetics in some detail. Maybe, in the ...
  • mTOR Inhibitors in Cancer, Aging and Health

    mTOR Inhibitors in Cancer, Aging and Health Marios Kyriazis MD When it comes to the regulation of aging mechanisms, one important molecule which has widespread effects is mTOR. This is the acronym of the mechanistic (previously also called ‘mammalian’) Target Of Rapamycin. It is a protein kinase which regulates the proliferation and development of cells. mTOR acts as a central controller in signalling pathways which regulate the survival and function of the cell...
  • The ultimate AGE inhibitors

    The ultimate AGE inhibitors We’ve known for several decades that the process of glycosylation is one of the most important causes of aging, perhaps equally as important as the process of oxidation. During our daily metabolism, sugar molecules, (such as glucose and fructose) and reactive aldehydes and/or ketones may combine to any free amino groups on proteins, a process called non-enzymatic glycosylation (glycation). This reaction is also sometimes called the Maillard reaction. It...
  • Carnosine Update

    Carnosine Update: New and existing functions of carnosine confirmed by research As many of you may know, one of my favourite nutritional supplements is carnosine. I recognised the potential of this nutrient over 10 years ago and started using it on many of my patients. Carnosine is an all round anti-ageing supplement, as it is an antioxidant, anti-glycator, a chelator of heavy metals (i.e. it inactivates any toxic metal ion...
  • Can-C eye drops – 10 years on

    Can-C eye drops – 10 years on The patented form of N-acetylcarnosine eye drops (Can-C) has been used for several years for the treatment of cataract and other eye conditions. Many thousands of patients have noticed improvement of their vision, ranging from mild improvement to complete resolution of the condition. According to the manufacturers of Can-C lubricant eye-drops, over half a million bottles were sold worldwide to-da...
  • An effective combination of the anti-aging compounds resveratrol, aminoguanidine, vinpocetine and carnosine

    An effective combination of the anti-aging compounds resveratrol, aminoguanidine, vinpocetine and carnosine In order to fight age-related degeneration, many anti-aging physicians and researchers recommend the intake of not one or two agents but a finely tuned combination of several compounds which have a wide spectrum of actions. In this article I am going to discuss my favourite combination of a few selected and pluripotent (i.e. having multiple actions) anti-aging compounds. These...
  • Interview with Dr Kyriazis about L-carnosine and N-acetylcarnosine

    Interview with Dr Kyriazis about L-carnosine and N-acetylcarnosine Marios Kyriazis M.D. is one of the leading anti-aging physicians in the UK. He is also one of the few researchers who has tested 'low dosages' of L-carnosine in humans for its anti-oxidant abilities. In this interview Dr. Kyriazis elaborates on those results and also upon the emergence of N-acetylcarnosine. Phil: 'Dr. Kyriazis, many thanks for taking time out of your busy schedule to talk to us today about yo...
  • The Cataract Cure about L-carnosine and N-acetylcarnosine

    The Cataract Cure about L-carnosine and N-acetylcarnosine Dr. Kyriazis is one of Britain’s top anti-aging physicians and is internationally recognised as a pioneer in the field. He is a bio-gerontologist with a medical degree and postgraduate degrees from King’s College, London and the Royal College of Physicians. He has written many books for both ...
  • Depression & SAMe

    Depression & SAMe Over 17 million Americans are affected by depression and yet many of these cases are never diagnosed or treated properly. Depression is characterized by persistent symptoms lasting for over two weeks. Symptoms include feelings of sadness and pessimism, loss of motivation or initiative, changes in sleep patterns and in appetite, bouts of crying and thoughts of suicide. There are many factors which can trigger depression but it is increasingly recognize...
  • Carnosine can Reduce Urinary MDA Concentration

    Low Dose Carnosine can Reduce Urinary MDA Concentration Dr. Marios Kyriazis is one of the few anti-aging physicians in the United Kingdom, he is also considered to be an expert on carnosine and has been actively involved in its research over the last few years. Indeed, his lecture at the Second Monte Carlo Antiaging Conference ™ was entitled "Carnosine, the new anti-aging di-peptide," and an audio-cassette is now available for purchase (please see order form or website)....
  • Carnosine - The New Anti-Aging Supplement

      Carnosine - The New Anti-Aging Supplement by Marios Kyriazis M.D.   *Please don't confuse this for the common amino acid CARNITINE (L-Carnitine). Although carnosine (also known as L-carnosine) has been known for about a century, its antiaging properties have only been extensively studied during the past few years. A recent literature review revealed over 780 published studies on carnosine, mainly by Russian and Japanese researchers. However, more wide...
  • A Patient's Assessment for Anti-Aging Medicine

      A Patient's Assessment for Anti-Aging Medicine By Marios Kyriazis M.D.   Ed.- Dr. Kyriazis is one of the UK's leading Anti-Aging Physicians and the founder and medical advisor to the British Longevity Society. He is also one of the few physician's worldwide who has conducted tests on aging but otherwise healthy individuals and the effective low dose use of L-carnosine, (as reported in the Winter 2001 IAS Anti-Aging Bulletin). Dr. Kyriazis spo...
  • Nutritional supplements to prevent age-related visual problems

      Nutritional supplements to prevent age-related visual problems Ed.- This article is based, and expands, on the book The Cataract Cure, by Marios Kyriazis M.D., published by iUniverse.   Chronic, age-related visual problems such as cataract, macular degeneration and glaucoma have one basic similarity. These are degenerative conditions caused by excessive oxidation (free radical damage). Remember that free radicals are toxic by-products of your everyday metabol...
  • Taking Supplements - Have We Got It Wrong

    Taking Supplements - Have We Got It Wrong The great majority, or perhaps all of you, reading this Antiaging Magazine take some nutritional supplements or other natural remedies. And it is very likely that you take these supplements at regular intervals, say once every day, or every 8 hours or whatever. This regularity in taking a certain supplement reflects the current, standard advice given by most medical practitioners and covers every prescription drug, supplement or natura...
  • Calorie Restriction Mimetics

    Calorie Restriction Mimetics The most reliable intervention which consistently increases the life-span of animals is calorie restriction (CR). This intervention does not only extend the 'average life-span' (the average number of years an animal is expected to live), but it also prolongs the 'maximum life-span', which is the maximum number of years a particular species can possibly reach. The maximum life-span of mice is 3 years, while that of chimpanzees is 50 years. The human...
  • Skin Aging: When the dimples become wrinkles

    Skin Aging: When the dimples become wrinkles While all components of the skin are affected by age without exception, some segments are more vulnerable than others. It is well accepted that components of the skin age at different rates and in different degrees. This is because of individual genetic variations, (mosaicism) which are superimposed upon variable external factors and influences such as sun exposure, diet and pollution (1). For example, the skin under the eyes may ap...
  • Cross-link Breakers and Inhibitors

    Cross-link Breakers and Inhibitors It is now well established that the process of glycosylation is one of the most important causes of ageing, perhaps equally as important as the process of oxidation (free radical damage). During everyday metabolism, sugar molecules (such as glucose and fructose), and reactive aldehydes and/or ketones may attach to free amino groups on proteins, a process called non-enzymatic glycosylation (glycation). This reaction is also sometimes called th...