Tetracycline: the effective and versatile antibiotic

Tetracycline antibiotics are commonly used for the treatment of infections caused by bacteria. These bacterial infections include a wide range of conditions like pneumonia and other respiratory tract infections, infections of the skin, genitals and urinary tracts. Tetracycline is also very effective as an acne treatment.

By hindering the bacteria’s ability to produce proteins that they need to survive and multiply, a Tetracycline dosage halts the further spread of infection. By stopping this growth and the sustained life of the bacteria, our immune systems can then kill off the infected bacteria. As many infections are bacterial, Tetracycline has a broad and adaptable range of conditions that it can be used for.

Tetracycline is a treatment that targets the bacteria responsible for certain diseases. As not all bacteria are bad (in fact some types of bacteria help our bodies), with Tetracycline infections can be specifically targeted. The body can then get on with repairing damaged cells and not have to concentrate solely on fighting the spread of the infection.

With tetracycline infections are stopped in their tracks

Bacterial infections can be caught a number of ways: through skin contact and bodily fluids passing from one person to another, through to being spread by coughing, or by swallowing the bacteria. They are more easily transmitted through our body’s cells that have mucous membranes than those covered by the protective layer of our skin.

Mucous membrane cells can be typically found in our respiratory passages, although they are found in other parts of our body too. The severity of the infections can vary but in many cases they can be treated by Tetracycline antibiotics.

Tetracycline has been traditionally used to address infections caused by chlamydia: the chest infection psittacosis, the eye infection trachoma, and genital and urinary infections like urethritis, together with mycoplasma organism-caused infections like pneumonia. Its versatility is not limited to these conditions though.

Wider uses for tetracycline

Tetracycline dosage can be used against long term re-appearances of bronchitis - which has its roots in a bacterium called haemophilus influenzae, as well as syphilis, gonorrhoea, infection caused by brucella bacteria (brucellosis), mycoplasma organisms, leptospirosis (Weil’s disease), gas gangrene, tetanus and cholera.

It also can be used to treat infections caused by rickettsia micro-organisms transmitted by lice, fleas, ticks and mites, such as Rocky Mountain spotted fever, typhus group, Q fever coxiella endocarditis and tick fevers.

How tetracycline curbs acne

Working as an agent against the bacteria associated with acne – propionibacterium acnes – Tetracycline for acne treatment is well known.

A very common skin disorder normally experienced by most young people in early puberty, acne can unfortunately still affect us in later life. To counter this, Tetracycline for acne works by stopping the bacteria that inflames the small oil glands known as the sebaceous glands.

The natural production of androgens in our bodies causes the production of sebum. As sebum is produced by our sebaceous glands, the increased production of sebum then narrows the openings of the sebaceous glands and stops the sebum leaving the skin.

The common bacterium propionibacterium acnes feed on the excess sebum and produce fatty acids and waste products, that also irritate the sebaceous glands and result in more spots.

Using Tetracycline antibiotics helps control bacterial numbers and therefore reduces fatty acids that clog pores and block glands.

The irritation and inflammation of the sebaceous glands is also reduced by treating the condition in this way. The skin can then start the healing process and stop reddening as the antibiotic eases the underlying cause.

Taking tetracycline

Tetracycline comes as a suspension (liquid) to take by mouth and as convenient Tetracycline capsules. These dosages are usually taken two to four times daily on an empty stomach, at least one hour before or two hours after meals or snacks.

Each Tetracycline dose should be taken with a full glass of water, and dairy products must be avoided due to the way Tetracycline works on bacteria.

Use Tetracycline for acne and a very wide range of conditions. For proven results in fighting bacterial infections and much more, the solution is Tetracycline.

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Tetracycline – The Safe, Versatile Treatment For Bacterial Infections

Tetracycline (from the chemical compound Tetracycline Hydrochloride) offers a host of benefits when it comes to fighting off bacterial infections. Primary among them is its versatility. There are dozens of uses for Tetracycline - sinus infections, urinary infections, cholera, tetanus, all the way through to the most popular application of Tetracycline for acne.

As well as the many uses for Tetracycline, further benefits include the convenience – it's available as a capsule or as a liquid taken orally. And it's relatively safe for such a potent, multi-faceted drug. Side effects are often mild and easily spotted. They include nausea, vomiting, and swelling of the mucous membranes. Recommended dosage is around 4-6 capsules daily, depending on the infection being treated.

INGREDIENTS:

Each capsule contains Main ingredient: 250 mg hydrochlorate tetracycline. 

ExcipientS:

Magnesium stearate, cornstarch, titanium dioxide, indigotin, gelatine.

AVAILABLE IN:

Boxed blister of 16 250-mg capsules 

PHARMACEUTICAL CLASSIFICATION:

Wide ranging anti-bacterial antibiotic

THERAPEUTIC INDICATIONS:

Infections resulting from micro-organisms that are sensitive to tetracycline, in particular:

  • Bacterial pneumonia and bronchial pneumonia
  • Acute infections in the urogenital area and renewal of acute phase
  • Surgical infections (infections of soft tissue, osteomyelitis)
  • Acute and subacute infections of the intestinal tract, bacterial and amoebic dysentery, dysenteric syndrome in adults and children
  • Acute and subacute endocarditis
  • Epidemic cerebrospinal meningitis and purulent meningitis in general
  • Brucellosis
  • Rickets
  • Problems related to ear, nose and throat (tonsillitis, otitis, sinusitis, mastoiditis), eyes (conjunctivitis, blepharitis, trachoma), gynaecological disorders (adnexitis, metritis, cervicitis, vulvovaginitis) and skin disorders (furuncolisis, impetigo).

CONTRAINDICATIONS:

Significant hypersensitivity towards tetracycline or other components of this drug.

PRECAUTIONS:

As occurs with other antibiotics, treatment with tetracycline can give rise to super-infections from bacterial agents or fungi.

Bear in mind the possibility of enterocolitis as a result of resistant staphylococci or from Clostridium difficile.  In the treatment of gonococcal infections, be aware of the risk of its concealing the symptoms of co-existing syphilis.  In such cases, it is advisable to carry out serological controls for at least 4 months. 

Given that tetracycline’s can depress prothrombinic activity, it may be necessary to adapt the dosages of anti-coagulants that may be used during the administration of tetracycline.

Long-term treatment cycles require periodic controls of the haematic constitution and hepatic and renal functioning. 

If tetracycline’s are employed in the treatment of infections from beta haemolytic Streptococcus (Group A), treatment should last no less than ten days.

Use during pregnancy, nursing and early childhood 

This product is only to be used during pregnancy, nursing and early childhood when absolutely necessary and always under a doctor’s direct supervision.

INTERACTIONS:

Taking this medicine with penicillin is inadvisable due to the possibility of interference following the respective anti-bacterial activities. 

Antacid preparations with aluminium, calcium, magnesium, in addition to dairy products reduce the oral absorption of tetracycline.  Their simultaneous ingestion should thus be avoided.

SPECIAL WARNING:

In bone tissue in the process of formation, tetracycline can cause a stable calcium complex to form, although no particularly harmful effects have been reported in man. The use of tetracycline during the period of tooth formation (second half of pregnancy, post-natal period and early childhood may cause yellow-brown pigmentation to form on permanent teeth.  This has been verified above all in prolonged treatment with these antibiotics but has also been observed following brief but repeated treatments.

Predisposed patients may suffer photosensitive reactions in the course of treatment.  Bear in mind this possibility and interrupt treatment as soon as any cutaneous erythema appears.

In subjects suffering from renal insufficiency even normal doses of tetracycline can cause an accumulation in the circulation with the chance of hepatic damage.  In such cases it is necessary to adapt the dosage to the level of renal functionality, resorting, depending on the individual case, to controls of haematic levels (which must never exceed 15 mcg/ml) and hepatic functioning. Moreover, it must be remembered that tetracycline’s prompt an anti-anabolic action that might aggravate states of renal insufficiency. 

To avoid irritating the oesophagus, take the product with a sufficient amount of water. 

Using this product may occasionally cause super-infections in sensitive organisms. 

Taking into account the possibility of resistant germs, when one is not sure of germ sensitivity with regard to the antibiotic, appropriate bacteriological tests are necessary.

Tetracycline should not be used as a priority treatment in staphylococcal infections or those of the primary respiratory tracts (pharingo-tonsillitis, etc) from beta-haemolytic Streptococcus (A). 

Tetracycline’s that are not in proper condition (expired) can produce polyuria, glycosuria, aminociduria, proteinuria.  Storing the product for too long in a warm, moist atmosphere can encourage the formation of nephrotoxic tetracycline derivatives.

KEEP THIS MEDICINE OUT OF THE REACH OF CHILDREN:

DIRECTIONS FOR USE:

Recommended daily oral dosage varies from 15 to 25 mg/kg of body weight. In very serious cases, the dosage may be increased according to the doctor’s criterion.

In an adult of average weight, this is in practice 4-6 250-mg capsules per day and thus one capsule every 6-4 hours. 

The duration of treatment depends on the subsiding of fever and overall health improvement.

Once the phase of acute fever has passed, it is advisable to prolong treatment, most likely with a reduced dosage, for some days in order to avoid the possibility of relapse.

In acute staphylococcic infections and brucellosis, it is a good idea to prolong the treatment (approximately 2 weeks).  With subacute bacterial endocarditis, the treatment should be extended to at least 6 weeks.

In each case the treatment will be stabilised by the doctor on the basis of the patient’s clinical response.

Should one or more doses be missed, consult the doctor who has prescribed it before resuming treatment, for the correct restoration of the therapeutic pattern.

ADVERSE EFFECTS:

Throughout tetracycline treatment the following side effects can be seen:

  • Gastroenteric symptoms: anorexia, nausea, vomiting, diarrhoea, glossitis and other inflammations of the mucous membranes
  • Cutaneous symptoms: eruptions of an erythematous or maculopapular nature
  • Hypersensitive reactions: urticarial eruptions, anaphylactic purpura, angioneurotic oedema
  • Haematological alterations: extremely rare cases of haemolytic anaemia, neutropenia, trombocytopenia and eosinophilia 

Should the patient notice any adverse effect other than those described here, he is advised to report it to his doctor or chemist.

WARNING!  FINAL DATE FOR USING AND STORING THIS MEDICINE

Do not use the medicine if the expiry date shown on its packaging has passed.  Remember that the expiry date shown refers to the unopened product when properly stored.

The above information is the translation of the manufacturer's insert. It is provided under the supplying company's terms and conditions and should not replace the advice of your personal physician.

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    Tetracycline: the effective and versatile antibiotic Tetracycline antibiotics are commonly used for the treatment of infections caused by bacteria. These bacterial infections include a wide range of conditions like pneumonia and other respiratory tract infections, infections of the skin, genitals and urinary tracts. Tetracycline is also very effective as... Tetracycline: the effective and...