Esnatri Cream - Want natural HRT?

For many years, the only treatment that has been offered to women to help them deal with the effects of the menopause has been to put them on hormone replacement therapy (HRT). Hormone replacement therapy is seen by many as the panacea for all ills afflicting women over a certain age but have you ever stopped to think just what it is that is on offer?

For many women, what they are actually being offered is a drug based on conjugated equine estrogens (CEE) - that is to say estrogens garnered from the urine of pregnant horses! It would seem to make sense to suggest that estrogens from horse urine are suitable for horses but are not necessarily suitable for women.

Others may be offered a drug therapy containing a synthesised hormone called medroxyprogesterone acetate which, like conjugated equine estrogens, has a biochemical structure different to the hormones produced naturally by the female body.

When first introduced hormone replacement therapy was regarded as having benefits that far outweighed the negatives of taking the drugs. Certain therapies were even promoted as being beneficial for healthy post-menopausal women in terms of heart health. But now, after decades of scientifically rigorous testing, views are changing.

The Women’s Health Initiative

In the U.S. the Women’s Health Initiative (WHI) was established. A multi-million dollar, 15-year project, sponsored by the National Institutes of Health (NIH) and National Heart, Lung, and Blood Institute (NHLBI), it was set up to study a number of aspects of post-menopausal women’s health. Over 160,000 women aged 50-79 were enrolled into the program which was seen to be “one of the most definitive, far-reaching clinical trials of post-menopausal women's health ever undertaken in the U.S.” (WHI). Enrolment was completed by 1998. The participants could choose to take part in one, two or all three of the WHI’s trial components – one of which was hormone therapy trials.

The hormone therapy trials examined the effects of combined hormones or estrogen-alone therapies on the prevention of coronary heart disease and osteoporotic fractures, and the associated risk for breast cancer. Participants either took the hormone pills or a placebo (inactive pill).

However, the “Estrogen plus Progestin” and the “Estrogen Alone” trials were stopped ahead of schedule in July 2002 and March 2004 respectively because of increased risks of cardiovascular disease and breast cancer in women taking the hormones compared with those taking the placebo. The overall risks were found to outweigh the benefits.

The researchers continued to follow-up the women even though they were no longer taking hormone treatment. In 2008 the WHI reported that 3 years after the women stopped taking the estrogen plus progestin hormones, they no longer faced an increased risk of cardiovascular disease (heart disease, stroke, and blood clots) compared with women who had been taking the placebo but their lower risk of colorectal cancer had gone too. On the other hand, their risks of all cancers had increased after stopping the hormones compared to those on the placebo. This led the researchers to conclude that even after stopping the hormones for a period of three years, mortality from all causes was somewhat higher in women who had taken active estrogen and progestin compared with those who had taken the placebo. This follow-up served “to confirm the study’s conclusion that combination hormone therapy (estrogen and progestin) should not be used to prevent disease in healthy, post-menopausal women.” (WHI)

This wide ranging research makes sobering reading. And, of course, it raises a very important question:

What is the alternative if you don’t want to take conventional Hormone replacement therapy (with it’s inherent risks), nor do you want to take alien horse estrogens, BUT, you still need to alleviate the symptoms associated with the menopause?

The answer lies with Esnatri Cream– the natural Hormone replacement therapy.

Why do we need Esnatri for Hormone replacement therapy?

Estrogens are a group of steroid hormones. In women, the three major naturally occurring estrogens are estradiol, estrone and estriol. They are usually present at significantly higher levels in women of reproductive age and serve a number of very important functions including the development of female secondary sex characteristics and the regulation of the menstrual cycle.

As a woman goes through the menopause (technically the day after a woman’s final period finishes but is generally taken to mean the whole of the menopause transition years), the production of most of the reproductive hormones, including the estrogens, diminishes. For about a third of women going through the menopause, this change will simply present itself as the cessation of her periods and the ending of her ability to bear children. Unfortunately, the remaining two-thirds will be affected either moderately or severely by a whole range of symptoms including hot flushes, sleep disturbances, mood swings, depression, fatigue, joint and muscle pain, back pain and decreasing bone mineral density which over time may lead to osteoporosis.

The basic premise behind Hormone replacement therapy is, therefore, to effectively try and replace what nature has taken away in order to try and alleviate these symptoms. However, as we have seen above, the negative effects of conventional Hormone replacement therapy may far outweigh the benefits. It is Esnatri Cream that is the alternative to conventional Hormone replacement therapy.

What is Esnatri Cream?

Esnatri Cream is a unique natural triple estrogen cream containing synthetically prepared human estrogens. It may seem ridiculous to use the word “natural” to describe a cream that contains synthetic hormones. However, the use of the word “natural” is used to recognise the fact that Esnatri Cream contains hormones that have a biochemical structure that matches that of the hormones in the female body that they are designed to replace. In other words, it’s as biochemically as close to the natural estrogens produced by a woman as possible.

The formulation for Esnatri Cream is based on research carried out by renowned hormone expert Jonathan Wright MD, medical Director of the Tacoma Clinic in Kent, Washington, who has treated over two thousand women with natural hormone replacement since the early 1980’s.

His work in this area has shown that it is not just enough for the biochemical structure of the synthetic hormones to mimic the estrogens that are naturally produced by the female body but that they should be combined in a ratio of 90% estriol, 7% estradiol and 3% estrone. This ratio is believed to be closest to that found inside a woman’s body. Again this emphasises the “natural” description – the homones are present in Esnatri Cream in the proportions that occur naturally.

Many conventional triple estrogen replacement therapies use a ratio of 80:10: 10 for estriol, estradiol, estrone respectively. Some therapies even ignore estriol altogether – as it is claimed by some pharmaceutical producers to be a weak estrogen. This would seem a little bizarre given that women naturally produce high levels of it. Why would the chemists know better than mother nature? Estriol is, in fact, vital as it is now known to have anti-cancer properties, which may be able to cancel out the carcinogenic effects attributed to estradiol and estrone.

How to use Esnatri Cream.

Using Esnatri Cream is simple as it is applied topically. Most women going through the menopause should use 1.5mg to 3.5mg (average 2mg) daily from day 1 of their menstrual cycle to day 25. They should then stop and repeat the same pattern the following month. The cream can be applied simply by using the fingertips to the face, neck, upper chest, and breasts, behind the knees or inner thighs. The application site should be rotated daily.

It is highly recommended that a progesterone cream should be used in combination with Esnatri Cream. This is because exposure to estrogen without progesterone has been associated with an increase in the risk of endometrial cancer. However, when progesterone is taken with estrogen there is no increased risk.


Estrogen replacement therapy should only take place under the care of your doctor. Do not use Esnatri Cream if you have suffered from, are suffering, or may be suffering from cancer.

Estrogen replacement should only take place under the care of a physician and should not be undertaken if you have suffered from, are suffering, or may be suffering from cancer. It is highly recommend that Progesterone be used in combination with Esnatri.

Estradiol and estrone levels can be monitored with the hormone test kit.

What our customers say...

90/7/3 is the closest natural formulation of the levels of estrogen in a woman's body.
Jonathan Wright MD, Natural Hormone Replacement For Women Over 45, Smart Publications, Petaluma, California.

What a relief it is to find a natural estrogen cream formulated to the latest findings.
L.S., New Jersey.

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