Releasing PRO™

Chemical: GHRP6 (growth hormone releasing peptide 6 secretagogue)

Ingredients: 5 ml solution with a total of 500 IUs (International Units)

Properties: GHRP6 stimulates the release of growth hormone (GH), a 191 amino acid polypeptide, and consequently, it stimulates growth, cell reproduction and most importantly, regeneration in humans and other animals. The anterior pituitary gland synthesizes and releases GH in a pulsatile manner, in response to these stimuli by the hypothalamus or externally with nasal spray administration of GHRP6. The largest and most predictable of these GH peaks occurs about an hour after onset of sleep with plasma levels of 13 to 72 ng/mL. Otherwise there is wide variation between days and individuals. Nearly fifty percent of GH secretion occurs during the third and fourth REM sleep stages. Surges of secretion during the day occur at 3- to 5-hour intervals. The plasma concentration of GH during these peaks may range from 5 to even 45 ng/mL. Between the peaks, basal GH levels are low, usually less than 5 ng/mL for most of the day and night.

A number of factors are known to affect GH secretion, such as age, sex, diet, exercise, stress, and other hormones. Young adolescents secrete GH at the rate of about 700 μg/day, while healthy adults secrete GH at the rate of about 400 μg/day. Sleep deprivation generally suppresses GH release, particularly after early adulthood. Adults with GH deficiency have a relative increase in fat mass and a relative decrease in muscle mass and, in many instances, decreased energy and quality of life. Claims for GH as an anti-aging treatment date back to 1990 when the New England Journal of Medicine published a study wherein GH was used to treat 12 men over 60 years of age. All the men showed statistically significant increases in lean body mass and bone mineral density, while the control group did not. The authors of the study noted that these improvements were the opposite of the changes that would normally occur over a 10- to 20-year aging period.

Directions: Apply one spray to each nostril 1 to 5 times per day (each spray is 10 IU). The maximum daily allowance for adults is 100 IU. The maximum dosage to be given at a one time is 20 IU.

Caution: Do not use with alcohol.

Contraindications and interactions:  GHRP6 and its downstream hormone, hGH is incompatible with ethanol use.

Side Effects: GH is produced by a secretagogue, GHRP6, and it has acceptable safety in light of its benefits. There are several possible side effects caused by GH. Rarely, patients can experience joint swelling, joint pain, carpal tunnel syndrome, and an increased risk of diabetes. In some cases, the patient can produce an immune response against GH. GH may also be a risk factor for Hodgkin's lymphoma. One survey of adults that had been treated with replacement cadaver GH (which has not been used anywhere in the world since 1985) during childhood showed a mildly increased incidence of colon cancer and prostate cancer, but linkage with the GH treatment was not established.

Intoxication and its treatment: No known intoxication except when used simultaneously with alcohol consumption. Avoid ethanol and all forms of alcoholic beverage.

Presentation and use: 5 ml spray bottle. (1) Remove cap and squeeze 3 times before the first spray. (2) Introduce the spray bottle vertically into one nostril and squeeze once. Repeat with the other nostril. The patient should then inhale gently. (3) Replace cap after use.

Storage: The preparation may be kept at room temperature providing it is in a cool and dry place out of sunlight; else it should be kept in the cooler part of a fridge (i.e. the door). Once opened use and discard after a month or two.

Precautions: Keep this and all other medicines out of the reach of children. This product is not intended for use by pregnant or lactating women. This information does not replace your physician’s advice, always seek and follow your physician’s advice.

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