Strodival - General Information:

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. [PubChem]

Pharmacology:

Strodival, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

Additional information about Strodival

Strodival Indication:

For the treatment of atrial fibrillation and flutter and heart failure.

Mechanism Of Action:

Strodival inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Strodival also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Drug Interactions:

Not Available

Food Interactions:

Not Available

Generic Name:

Ouabain

Synonyms:

Ouabain Octahydrate; Ouabain, Octahydrate; Ouabaine; G-Strophanthin; Ouabagenin L-Rhamnoside; Strophanthin G; Strophanthin-G

Drug Category:

Cardiotonic Agents

Drug Type:

Small Molecule; Approved

Other Brand Names containing Ouabain:

Acocantherin; Astrobain; G-Strophicor; Gratibain; Gratus Strophanthin; Kombetin; Purostrophan; Rectobaina; Solufantina; Strodival; Strophalen; Strophoperm; Strophosan; Uabaina; Uabanin;
The above information is the translation of the manufacturer's insert. It is provided under the supplying company's terms and conditions and should not replace the advice of your personal physician.